Preparation and characterization of polymeric cross-linked hydrogel patch for topical delivery of gentamicin

Abstract This research aimed to prepare and characterize a new type of polymeric cross-linked topical hydrogel patches for the treatment wound infections. The free radical polymerization method was used by utilizing natural polymers, i.e., agarose gelatin. These polymers were chemically with monomer (acrylic acid) using ammonium persulfate as an initiator via cross-linker N , methylene bisacrylamide. An antibiotic, gentamicin sulfate loaded into designed system. made in spherical shape, which revealed be stable elastic. Fourier transform infrared spectroscopy, scanning electron microscopy, differential calorimetry, thermogravimetric analysis, X-ray powder diffraction investigation patches. Polymeric evaluated their sol–gel swelling studies, vitro drug release studies against pH 5.5, 6.5, 7.4, ex vivo permeation, deposition study on rabbit’s skin Franz diffusion cell. In addition, irritation healing performance drug-loaded also assessed compared commercially available formulations. found non-irritating up 72 h determined Draize patch test when marketed formulations, these resulted faster healing. prepared formulation showed promising potential infection.